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Sarilumab COVID Improving patient care through guidelines, evidence summaries and decision aids that we can all trust, use and share. Patients severely or critically ill with COVID-19 often suffer from an overreaction of the immune system, which can be very harmful to the patient’s health. This list is not complete and many other drugs may affect Kevzara. Sarilumab should be considered in place of tocilizumab (in women with COVID who have CRP>75 and are in, or need ICU admission). If you have rheumatoid arthritis, or another autoimmune or inflammatory condition, there may be too much of … Interleukin-6 Receptor Antagonists in Critically Ill ... Médicaments contre le Covid inhibitors (tocilizumab or sarilumab) for hospitalised patients with COVID-19 (adults) 12 September 2021 Commissioning position The proposal is: IL-6 inhibitors tocilizumab and sarilumab are recommended to be available as treatment options through routine commissioning for adult patients (aged 18 years and Tocilizumab Interleukin-6 blocking drugs – tocilizumab and sarilumab – act to suppress this overreaction. Tocilizumab is a biological therapy and can be prescribed for rheumatoid arthritis (roo-ma-toy-d arth-ri-tus), juvenile idiopathic arthritis (JIA) or giant cell arteritis.. A careful risk assessment should be done on the benefits of this off-label use to the mother, and the risks it poses to the fetus or neonate. People with an underlying health condition like rheumatoid arthritis should be … Tocilizumab ES34 Sarilumab for COVID-19 PDF 2.24 MB 23 March 2021 . Tocilizumab Labs (baseline only for tocilizumab): IL-6 ADULT COVID TREATMENT PROTOCOL Protocol version 2021_9_30 COVID-19 Infectious Diseases Pagers & Link: p8902: ID Consults for COVID and non-COVID patients ... Sarilumab 400 mg x 1 Tocilizumab 8 mg/kg x1; Max 800 mg Not recommended if LFTs > 5x ULN PARIS, Dec 3 — After a year of vaccines aimed at preventing Covid, treatments for people infected with the virus are few, with most restricted to hospital use and extremely pricey. Tell your doctor about all your current medicines. N Engl J Med. Alla luce delle attuali conoscenze si ritiene che sarilumab possa essere utilizzato in alternativa a tocilizumab quando quest’ultimo non fosse disponibile, per il trattamento di soggetti adulti ospedalizzati con COVID-19 grave e/o con livelli elevati degli indici di infiammazione sistemica. ES34 Sarilumab for COVID-19 PDF 2.24 MB 23 March 2021 . Les Tocilizumab et Sarilumab sont quant à eux des anticorps monoclonaux que l'on doit à Sanofi, et qui savent imiter la façon dont lutte le système immunitaire face au Covid-19. If baricitinib and IV tocilizumab are not available or not feasible to use, tofacitinib can be used instead of baricitinib (BIIa) and IV sarilumab can be used instead of IV tocilizumab (BIIa). PLACID Trial Collaborators. Questions listed below are related to the contraindications, precautions and special considerations for ... tocilizumab or sarilumab. … Sarilumab. 2020 Dec 10;383(24):2333-2344. doi: 10.1056/NEJMoa2028836 [ PubMed ] 33093056 Agarwal A, Mukherjee A, Kumar G, et al. Following treatment for COVID-19 with tocilizumab, sarilumab, or steroids, clinicians should provide suitable patient information leaflets at discharge Purpose Forms attached to this page can be used by clinicians with patients to support the discharge process. In critically ill patients with Covid-19 receiving organ support in ICUs, treatment with the interleukin-6 receptor antagonists tocilizumab and sarilumab improved outcomes, including survival. Dexaméthasone. Tocilizumab nella terapia dei pazienti adulti con COVID-19 CTS, 09 giugno 2021 ... 2.91) per una maggiore efficacia associata rispettivamente a tocilizumab e sarilumab rispetto a nessuna modulazione immunitaria, con un alto grado di certezza statistica (con una probabilità di Researchers think some RA drugs might help prevent or treat COVID-19. The Panel recommends against the use of baricitinib in combination with tocilizumab for the treatment of COVID-19, except in a clinical trial (AIII) . The Panel recommends against the use of baricitinib in combination with tocilizumab for the treatment of COVID-19, except in a clinical trial (AIII) . A careful risk assessment should be done on the benefits of this off-label use to the mother, and the risks it poses to the fetus or neonate. Labs (baseline only for tocilizumab): IL-6 ADULT COVID TREATMENT PROTOCOL Protocol version 2021_9_30 COVID-19 Infectious Diseases Pagers & Link: p8902: ID Consults for COVID and non-COVID patients ... Sarilumab 400 mg x 1 Tocilizumab 8 mg/kg x1; Max 800 mg Not recommended if LFTs > 5x ULN N Engl J Med. COVID-19, hospitalized patients (off-label use): Note: Under the emergency use authorization (EUA), use should be limited to patients with COVID-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) (FDA 2021). An IL-6 receptor antibody, tocilizumab, initially approved for rheumatoid arthritis has been approved for off-label use against COVID-19. Many drugs can interact with sarilumab, especially: any other medicines to treat rheumatoid arthritis, such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab, or tofacitinib. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. Tocilizumab nella terapia dei pazienti adulti con COVID-19 CTS, 09 giugno 2021 ... 2.91) per una maggiore efficacia associata rispettivamente a tocilizumab e sarilumab rispetto a nessuna modulazione immunitaria, con un alto grado di certezza statistica (con una probabilità di Interleukin-6 blocking drugs – tocilizumab and sarilumab – act to suppress this overreaction. US guideline recommendations on the role of … COVID-19 Tocilizumab & Sarilumab Treatment Protocol Tocilizumab and sarilumab are recombinant humanised monoclonal antibodies that block the interleukin-6 (IL-6) receptor, potentially mitigating the IL-6 mediated systemic and local effects seen within COVID-19. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. Tocilizumab is a biological therapy and can be prescribed for rheumatoid arthritis (roo-ma-toy-d arth-ri-tus), juvenile idiopathic arthritis (JIA) or giant cell arteritis.. Sarilumab should be considered in place of tocilizumab (in women with COVID who have CRP>75 and are in, or need ICU admission). Abstract Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. 10. This list is not complete and many other drugs may affect Kevzara. Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of arthritis in children.It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Dexaméthasone. Tocilizumab nella terapia dei pazienti adulti con COVID-19 CTS, 09 giugno 2021 ... 2.91) per una maggiore efficacia associata rispettivamente a tocilizumab e sarilumab rispetto a nessuna modulazione immunitaria, con un alto grado di certezza statistica (con una probabilità di This list is not complete and many other drugs may affect Kevzara. Implementation support. Following treatment for COVID-19 with tocilizumab, sarilumab, or steroids, clinicians should provide suitable patient information leaflets at discharge Purpose Forms attached to this page can be used by clinicians with patients to support the discharge process. Actemra Shortage: What to Do If You Have Issues Accessing This Biologic Because of COVID-19. COVID-19 mRNA Vaccine 3rd Dose Eligibility Immunosuppressing Medications Updated: August 16, 2021 Examples of medication that typically are immunosuppressing include: • Abatacept (Orencia) • Adalimumab (Humira) • Alemtuzumab (Lemtrada) within the past 3 years • Alkylating agents inc. • Anakinra (Kineret) Morbus Still) und der Riesenzellarteriitis.Seit Dezember 2021 ist Tocilizumab auch für die … Several agents that target the IL-6 pathway have been evaluated in randomized trials for treatment of COVID-19; these include the IL-6 receptor blockers tocilizumab and sarilumab and the direct IL-6 inhibitor siltuximab. Here is a look at treatment options available to Covid … inhibitors (tocilizumab or sarilumab) for hospitalised patients with COVID-19 (adults) 12 September 2021 Commissioning position The proposal is: IL-6 inhibitors tocilizumab and sarilumab are recommended to be available as treatment options through routine commissioning for adult patients (aged 18 years and ES33 Tocilizumab for COVID-19 PDF 1.89 MB 23 March 2021 . COVID-19, hospitalized patients (off-label use): Note: Under the emergency use authorization (EUA), use should be limited to patients with COVID-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) (FDA 2021). If you have rheumatoid arthritis, or another autoimmune or inflammatory condition, there may be too much of … Implementation support. Immunocompromising MedicationsPatients who are actively taking immune-suppressing or modulating medications on the following (alphabetized) list compiled by UConn Health physicians may be eligible for a third dose of COVID-19 vaccine. Alla luce delle attuali conoscenze si ritiene che sarilumab possa essere utilizzato in alternativa a tocilizumab quando quest’ultimo non fosse disponibile, per il trattamento di soggetti adulti ospedalizzati con COVID-19 grave e/o con livelli elevati degli indici di infiammazione sistemica. Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of arthritis in children.It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Sarilumab should be considered in place of tocilizumab (in women with COVID who have CRP>75 and are in, or need ICU admission). Sarilumab is an anti-IL-6 receptor antibody that has an affinity to the IL-6 receptor α chain that is 20 times greater than that of tocilizumab. The REMAP-CAP trial has reported with tocilizumab or sarilumab an overall Here is a look at treatment options available to Covid … Many drugs can interact with sarilumab, especially: any other medicines to treat rheumatoid arthritis, such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab, or tofacitinib. A single UK Interim Clinical Commissioning Policy has now been published, recommending that equal consideration is given to two potential interleukin-6 (IL-6) inhibitor treatment options - tocilizumab or sarilumab - for adult patients (aged 18 years and older) hospitalised due to COVID-19 in accordance with the agreed criteria. COVID-19 mRNA Vaccine 3rd Dose Eligibility Immunosuppressing Medications Updated: August 16, 2021 Examples of medication that typically are immunosuppressing include: • Abatacept (Orencia) • Adalimumab (Humira) • Alemtuzumab (Lemtrada) within the past 3 years • Alkylating agents inc. • Anakinra (Kineret) Questions listed below are related to the contraindications, precautions and special considerations for ... tocilizumab or sarilumab. Dexaméthasone. We aimed to assess the ability of sarilumab to improve the outcome of patients hospitalised with moderate-to-severe COVID-19 pneumonia. Morbus Still) und der Riesenzellarteriitis.Seit Dezember 2021 ist Tocilizumab auch für die … An IL-6 receptor antibody, tocilizumab, initially approved for rheumatoid arthritis has been approved for off-label use against COVID-19. People with an underlying health condition like rheumatoid arthritis should be … (REMAP-CAP ClinicalTrials.gov number, NCT02735707. Following treatment for COVID-19 with tocilizumab, sarilumab, or steroids, clinicians should provide suitable patient information leaflets at discharge Purpose Forms attached to this page can be used by clinicians with patients to support the discharge process. Sarilumab. Sarilumab is a recombinant humanized anti-IL-6 receptor mAb that is approved by the FDA for use in patients with rheumatoid arthritis. (REMAP-CAP ClinicalTrials.gov number, NCT02735707. The Panel recommends against the use of baricitinib in combination with tocilizumab for the treatment of COVID-19, except in a clinical trial (AIII) . A single UK Interim Clinical Commissioning Policy has now been published, recommending that equal consideration is given to two potential interleukin-6 (IL-6) inhibitor treatment options - tocilizumab or sarilumab - for adult patients (aged 18 years and older) hospitalised due to COVID-19 in accordance with the agreed criteria. (REMAP-CAP ClinicalTrials.gov number, NCT02735707. Sarilumab is an anti-IL-6 receptor antibody that has an affinity to the IL-6 receptor α chain that is 20 times greater than that of tocilizumab. inhibitors (tocilizumab or sarilumab) for hospitalised patients with COVID-19 (adults) 12 September 2021 Commissioning position The proposal is: IL-6 inhibitors tocilizumab and sarilumab are recommended to be available as treatment options through routine commissioning for adult patients (aged 18 years and Sarilumab is a recombinant humanized anti-IL-6 receptor mAb that is approved by the FDA for use in patients with rheumatoid arthritis. Tocilizumab is a monoclonal antibody against interleukin-6 receptor-alpha that is used to treat certain inflammatory diseases. Questions listed below are related to the contraindications, precautions and special considerations for ... tocilizumab or sarilumab. Tocilizumab is a monoclonal antibody against interleukin-6 receptor-alpha that is used to treat certain inflammatory diseases. US guideline recommendations on the role of … Sarilumab. US guideline recommendations on the role of … [8] Ronapreve (REGN-COV2) The spike protein is a key mediator of viral infectivity required for attachment and entry … Actemra Shortage: What to Do If You Have Issues Accessing This Biologic Because of COVID-19. COVID-19 Tocilizumab & Sarilumab Treatment Protocol Tocilizumab and sarilumab are recombinant humanised monoclonal antibodies that block the interleukin-6 (IL-6) receptor, potentially mitigating the IL-6 mediated systemic and local effects seen within COVID-19. ES34 Sarilumab for COVID-19 PDF 2.24 MB 23 March 2021 . We aimed to assess the ability of sarilumab to improve the outcome of patients hospitalised with moderate-to-severe COVID-19 pneumonia. Labs (baseline only for tocilizumab): IL-6 ADULT COVID TREATMENT PROTOCOL Protocol version 2021_9_30 COVID-19 Infectious Diseases Pagers & Link: p8902: ID Consults for COVID and non-COVID patients ... Sarilumab 400 mg x 1 Tocilizumab 8 mg/kg x1; Max 800 mg Not recommended if LFTs > 5x ULN Tocilizumab is a biological therapy and can be prescribed for rheumatoid arthritis (roo-ma-toy-d arth-ri-tus), juvenile idiopathic arthritis (JIA) or giant cell arteritis.. Patients severely or critically ill with COVID-19 often suffer from an overreaction of the immune system, which can be very harmful to the patient’s health. 10. Tell your doctor about all your current medicines. Tocilizumab (Handelsnamen RoActemra ® (EU), Actemra ® (CH); Hersteller Hoffmann-La Roche) ist ein humanisierter monoklonaler Antikörper gegen den Interleukin-6 (IL-6)-Rezeptor zur Behandlung der rheumatoiden Arthritis (RA), der systemischen juvenilen idiopathischen Arthritis (sJIA; Syn. The REMAP-CAP trial has reported with tocilizumab or sarilumab an overall Many drugs can interact with sarilumab, especially: any other medicines to treat rheumatoid arthritis, such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab, or tofacitinib. ). 8. Several agents that target the IL-6 pathway have been evaluated in randomized trials for treatment of COVID-19; these include the IL-6 receptor blockers tocilizumab and sarilumab and the direct IL-6 inhibitor siltuximab. 8. ES33 Tocilizumab for COVID-19 PDF 1.89 MB 23 March 2021 . Immunocompromising MedicationsPatients who are actively taking immune-suppressing or modulating medications on the following (alphabetized) list compiled by UConn Health physicians may be eligible for a third dose of COVID-19 vaccine. Sarilumab is an anti-IL-6 receptor antibody that has an affinity to the IL-6 receptor α chain that is 20 times greater than that of tocilizumab. Several agents that target the IL-6 pathway have been evaluated in randomized trials for treatment of COVID-19; these include the IL-6 receptor blockers tocilizumab and sarilumab and the direct IL-6 inhibitor siltuximab. In critically ill patients with Covid-19 receiving organ support in ICUs, treatment with the interleukin-6 receptor antagonists tocilizumab and sarilumab improved outcomes, including survival. PLACID Trial Collaborators. 10. COVID-19 Vaccine Screening Checklist This resource is intended to assist healthcare providers while conducting an informed consent conversation and health assessment with a client. Actemra Shortage: What to Do If You Have Issues Accessing This Biologic Because of COVID-19. PUBLISHED 09/07/21 BY Kelsey Kloss Tocilizumab (Actemra), which is used to treat rheumatoid and other inflammatory arthritis, is in short supply due to its emergency use authorization (EUA) as a COVID-19 treatment. COVID-19 Vaccine Screening Checklist This resource is intended to assist healthcare providers while conducting an informed consent conversation and health assessment with a client. Tocilizumab and sarilumab (another interleukin-6 receptor antagonist) were evaluated in critically ill patients with COVID-19 ( including mechanically ventilated patients) showed improvement in clinical outcome and survival of note the patients were recruited early to the trial arms within 24 hours of starting organ support in the ICU. COVID-19 Tocilizumab & Sarilumab Treatment Protocol Tocilizumab and sarilumab are recombinant humanised monoclonal antibodies that block the interleukin-6 (IL-6) receptor, potentially mitigating the IL-6 mediated systemic and local effects seen within COVID-19. Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of arthritis in children.It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). If you have rheumatoid arthritis, or another autoimmune or inflammatory condition, there may be too much of … Tocilizumab is a monoclonal antibody against interleukin-6 receptor-alpha that is used to treat certain inflammatory diseases. Alla luce delle attuali conoscenze si ritiene che sarilumab possa essere utilizzato in alternativa a tocilizumab quando quest’ultimo non fosse disponibile, per il trattamento di soggetti adulti ospedalizzati con COVID-19 grave e/o con livelli elevati degli indici di infiammazione sistemica. Researchers think some RA drugs might help prevent or treat COVID-19. The REMAP-CAP trial has reported with tocilizumab or sarilumab an overall Tocilizumab and sarilumab (another interleukin-6 receptor antagonist) were evaluated in critically ill patients with COVID-19 ( including mechanically ventilated patients) showed improvement in clinical outcome and survival of note the patients were recruited early to the trial arms within 24 hours of starting organ support in the ICU. People with an underlying health condition like rheumatoid arthritis should be … If there is a local or regional shortage of tocilizumab, sarilumab can be used as an alternative (see Therapeutic Management of Hospitalized Adults With COVID-19). … ). 2020 Dec 10;383(24):2333-2344. doi: 10.1056/NEJMoa2028836 [ PubMed ] 33093056 Agarwal A, Mukherjee A, Kumar G, et al. We aimed to assess the ability of sarilumab to improve the outcome of patients hospitalised with moderate-to-severe COVID-19 pneumonia. … An IL-6 receptor antibody, tocilizumab, initially approved for rheumatoid arthritis has been approved for off-label use against COVID-19. If there is a local or regional shortage of tocilizumab, sarilumab can be used as an alternative (see Therapeutic Management of Hospitalized Adults With COVID-19). Patients severely or critically ill with COVID-19 often suffer from an overreaction of the immune system, which can be very harmful to the patient’s health. 2020 Dec 10;383(24):2333-2344. doi: 10.1056/NEJMoa2028836 [ PubMed ] 33093056 Agarwal A, Mukherjee A, Kumar G, et al. COVID-19 mRNA Vaccine 3rd Dose Eligibility Immunosuppressing Medications Updated: August 16, 2021 Examples of medication that typically are immunosuppressing include: • Abatacept (Orencia) • Adalimumab (Humira) • Alemtuzumab (Lemtrada) within the past 3 years • Alkylating agents inc. • Anakinra (Kineret) PLACID Trial Collaborators. Likewise, sarilumab, another IL-6 antibody, is also under trials for the treatment of COVID-19. Abstract Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. Abstract Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. A single UK Interim Clinical Commissioning Policy has now been published, recommending that equal consideration is given to two potential interleukin-6 (IL-6) inhibitor treatment options - tocilizumab or sarilumab - for adult patients (aged 18 years and older) hospitalised due to COVID-19 in accordance with the agreed criteria. In critically ill patients with Covid-19 receiving organ support in ICUs, treatment with the interleukin-6 receptor antagonists tocilizumab and sarilumab improved outcomes, including survival. Interleukin-6 blocking drugs – tocilizumab and sarilumab – act to suppress this overreaction. PUBLISHED 09/07/21 BY Kelsey Kloss Tocilizumab (Actemra), which is used to treat rheumatoid and other inflammatory arthritis, is in short supply due to its emergency use authorization (EUA) as a COVID-19 treatment. Sarilumab is a recombinant humanized anti-IL-6 receptor mAb that is approved by the FDA for use in patients with rheumatoid arthritis. COVID-19 Vaccine Screening Checklist This resource is intended to assist healthcare providers while conducting an informed consent conversation and health assessment with a client. ). Likewise, sarilumab, another IL-6 antibody, is also under trials for the treatment of COVID-19. If baricitinib and IV tocilizumab are not available or not feasible to use, tofacitinib can be used instead of baricitinib (BIIa) and IV sarilumab can be used instead of IV tocilizumab (BIIa). Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. A careful risk assessment should be done on the benefits of this off-label use to the mother, and the risks it poses to the fetus or neonate. 8. Immunocompromising MedicationsPatients who are actively taking immune-suppressing or modulating medications on the following (alphabetized) list compiled by UConn Health physicians may be eligible for a third dose of COVID-19 vaccine. Les Tocilizumab et Sarilumab sont quant à eux des anticorps monoclonaux que l'on doit à Sanofi, et qui savent imiter la façon dont lutte le système immunitaire face au Covid-19. Improving patient care through guidelines, evidence summaries and decision aids that we can all trust, use and share. PUBLISHED 09/07/21 BY Kelsey Kloss Tocilizumab (Actemra), which is used to treat rheumatoid and other inflammatory arthritis, is in short supply due to its emergency use authorization (EUA) as a COVID-19 treatment. Here is a look at treatment options available to Covid … ES33 Tocilizumab for COVID-19 PDF 1.89 MB 23 March 2021 . Tell your doctor about all your current medicines. If there is a local or regional shortage of tocilizumab, sarilumab can be used as an alternative (see Therapeutic Management of Hospitalized Adults With COVID-19). PARIS, Dec 3 — After a year of vaccines aimed at preventing Covid, treatments for people infected with the virus are few, with most restricted to hospital use and extremely pricey. Tocilizumab and sarilumab (another interleukin-6 receptor antagonist) were evaluated in critically ill patients with COVID-19 ( including mechanically ventilated patients) showed improvement in clinical outcome and survival of note the patients were recruited early to the trial arms within 24 hours of starting organ support in the ICU. PARIS, Dec 3 — After a year of vaccines aimed at preventing Covid, treatments for people infected with the virus are few, with most restricted to hospital use and extremely pricey. N Engl J Med. COVID-19, hospitalized patients (off-label use): Note: Under the emergency use authorization (EUA), use should be limited to patients with COVID-19 who are receiving systemic corticosteroids and require supplemental oxygen, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) (FDA 2021). Implementation support. Tocilizumab (Handelsnamen RoActemra ® (EU), Actemra ® (CH); Hersteller Hoffmann-La Roche) ist ein humanisierter monoklonaler Antikörper gegen den Interleukin-6 (IL-6)-Rezeptor zur Behandlung der rheumatoiden Arthritis (RA), der systemischen juvenilen idiopathischen Arthritis (sJIA; Syn. Les Tocilizumab et Sarilumab sont quant à eux des anticorps monoclonaux que l'on doit à Sanofi, et qui savent imiter la façon dont lutte le système immunitaire face au Covid-19. 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